For this special issue of the International Migration Review, we develop and provide a comprehensive organizing framework, the Migration Intersections Grid (MIG), to inform and guide migration research in and through the remainder of the twenty-first century. We motivate our work by conducting a high-level scoping review of summaries and syntheses of different directions of travel in migration research over time. Informed by these results, we then identify and describe 12 components that constitute the MIG, which, as we later discuss, is an interactive intersectional organizing framework. Finally, we illustrate the MIG’s interactive intersectional nature by applying it to several areas of migration research where a comprehensive organizing framework of this sort is needed to address existing and emerging issues and questions now and in the coming decades.